St-Pierre lab | Publications

2026

2026 - Nature Methods

Designer indicators for two-photon recording of subthreshold voltage dynamics

Land, M. A., Galdamez, M., Villette, V., Zhu, J., Lu, X., Marosi, M., ... & St-Pierre, F. (2026)

2026 - bioRxiv

A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivo

McDonald, A. J., Land, M. A., Yang, S., Hakam, N., Villette, V., Zhu, J., ... & St-Pierre, F. (2026). A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivo. bioRxiv.

2026 - Neuron

Movement-stabilized three-dimensional optical recordings of membrane potential changes and calcium dynamics in hippocampal CA1 dendrites

Gonzalez, K. C., Terada, S., Noguchi, A., Zakka, G. N., O’Toole, C., Bilbao, G., ... & Rózsa, B. (2026).

2026 - bioRxiv

A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo.

Yang, S., McDonald, A. J., Lu, X., Villette, V., Hakam, N., Galdamez, M., ... & St-Pierre, F. (2026).

2025 - Cell Reports

High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement

Spencer T. Brown , Meghana R. Holla, Michelle A. Land, Shuyuan Yang, Alex J. McDonald, François St-Pierre & Indira M. Raman

2025 - Nature Communications

All-optical voltage interrogation for probing synaptic plasticity in vivo

Carolan, J., Land, M. A., Lu, X., Beau, M., Kostadinov, D., St-Pierre, F., Clark, BA., Häusser, M.

2025 - Nature Communications

Bright and photostable yellow fluorescent proteins for extended imaging

Jihwan Lee , Shujuan Lai, Shuyuan Yang, Shiqun Zhao, Francisco A. Blanco, Anne C. Lyons, Raquel Merino-Urteaga, John F. Ahrens, Nathan A. Nguyen, Haixin Liu, Zhuohe Liu, Gerard G. Lambert, Nathan C. Shaner, Liangyi Chen, Kimberley F. Tolias, Jin Zhang, Taekjip Ha & François St-Pierre

2025 - Nature Methods

FACED 2.0 enables large-scale voltage and calcium imaging in vivo

Jian Zhong, Ryan G. Natan, Qinrong Zhang, Justin S. J. Wong, Christoph Miehl, Krishnashish Bose, Xiaoyu Lu, François St-Pierre, Su Guo, Brent Doiron, Kevin K. Tsia & Na Ji

2025 - eLife

Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics

Govorunova, E. G., Sineshchekov, O. A., Li, H., Gou, Y., Chen, H., Yang, S., Wang, Y., Mitchell, S., Palmateer, A., Brown, S. L., St-Pierre, F., Xue, M., Spudich, J. L.

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2022 - Cell

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Zhuohe Liu, Xiaoyu Lu, Vincent Villette, Yueyang,Gou, Kevin L. Colbert, Shujuan Lai, Sihui Guan, Michelle A. Land, Jihwan Lee, Tensae Assefa, Daniel R. Zollinger, Maria M. Korympidou, Anna L. Vlasits, Michelle M. Pang, Sharon Su, Changjia Cai, Emmanouil Froudarakis, Na Zhou, Saumil S. Patel, Cameron L. Smith, Annick Ayon, Pierre Bizouard, Jonathan Bradley, Katrin Franke, Thomas R. Clandinin, Andrea Giovannucci, Andreas S. Tolias, Jacob Reimer, Stéphane Dieudonné & François St-Pierre

2022 - Nature Scientific Reports

A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3

Benjamin B. Kim, Haodi Wu, Yukun A. Hao, Michael Pan, Mariya Chavarha, Yufeng Zhao, Michael Westberg, François St-Pierre, Joseph C. Wu & Michael Z. Lin

2022 - Biochemistry

Automating the High-Throughput Screening of Protein-Based Optical Indicators and Actuators

Jihwan Lee, Beatriz Campillo, Shaminta Hamidian, Zhuohe Liu, Matthew Shorey & François St-Pierre

2022 - Current Biology

Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling

Christian Behrens, Shubhash Chandra Yadav, Maria M. Korympidou, Yue Zhang, Silke Haverkamp, Stephan Irsen, Anna Schaedler, Xiaoyu Lu, Zhuohe Liu, Jan Lause, François St-Pierre, Katrin Franke, Anna Vlasits, Karin Dedek, Robert G. Smith, Thomas Euler, Philipp Berens & Timm Schubert

2022 - Nature Neuroscience

Kallum channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition

Elena G. Govorunova, Yueyang Gou, Oleg A. Sineshchekov, Hai Li, Xiaoyu Lu, Yumei Wang, Leonid S. Brown, François St-Pierre, Mingshan Xue & John L. Spudich

2024 - Nature Communications

Scanless two-photon voltage imaging

Ruth R. Sims, Imane Bendifallah, Christiane Grimm, Aysha S. Mohamed Lafirdeen, Soledad Domínguez, Chung Yuen Chan, Xiaoyu Lu, Benoît C. Forget, François St-Pierre, Eirini Papagiakoumou & Valentina Emiliani

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2023 - Nature Communications

Wideﬁeld imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy

Xiaoyu Lu, Yunmiao Wang, Zhuohe Liu, Yueyang Gou, Dieter Jaeger & François St-Pierre

2020-2021

2021 - Nature Reviews Chemistry

A blueprint for glow tag engineering

Jihwan Lee & François St-Pierre

2020 - Science Advances

Versatile phenotype-activated cell sorting

Jihwan Lee, Zhuohe Liu, Peter H. Suzuki, John F. Ahrens, Shujuan Lai, Xiaoyu Lu, Sihui Guan & François St-Pierre

2021 - Science Advances

Ancestral circuits for vertebrate color vision emerge at the first retinal synapse

Takeshi Yoshimatsu, Philipp Bartel, Cornelius Schroder, Filip K. Janiak, François St-Pierre, Philipp Berens & Tom Baden

2021 - Nature Communications

A synthetic circuit for buffering gene dosage variation between individual mammalian cells

Ji Yang, Jihwan Lee, Michelle A. Land, Shujuan Lai, Oleg A. Igoshin & François St-Pierre

2019 - Cell

Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice

Vincent Villette, Mariya Chavarha, Ivan K.Dimov, Jonathan Bradley, Lagnajeet Pradhan, Benjamin Mathieu, Stephen W.Evans, Simon Chamberland, Dongqing Shi, Renzhi Yang, Benjamin B.Kim, Annick Ayon, Abdelali Jalil, François St-Pierre, Mark J.Schnitzer, Guoqiang Bi, Katalin Toth, Jun Ding, Stéphane Dieudonné & Michael Z. Lin

2016 - Cell

Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice

Jesse D Marshall, Jin Zhong Li, Yanping Zhang, Yiyang Gong, François St-Pierre, Michael Z Lin & Mark J Schnitzer

2014 - Nature Neuroscience

High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

François St-Pierre, Jesse D Marshall, Ying Yang, Yiyang Gong, Mark J Schnitzer & Michael Z Lin

2012 - Nature Methods

Improving FRET dynamic range with bright green and red fluorescent proteins

Amy J Lam, François St-Pierre, Yiyang Gong, Jesse D Marshall, Paula J Cranfill, Michelle A Baird, Michael R McKeown, Jörg Wiedenmann, Michael W Davidson, Mark J Schnitzer, Roger Y Tsien & Michael Z Lin

2017 - Elife

Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators

Simon Chamberland, Helen H Yang, Michael M Pan, Stephen W Evans, Sihui Guan, Mariya Chavarha, Ying Yang, Charleen Salesse, Haodi Wu, Joseph C Wu, Thomas R Clandinin , Katalin Toth , Michael Z Lin & François St-Pierre

2016 - Cell

Subcellular Imaging of Voltage and Calcium Signals Reveals Neural Processing In Vivo

Helen H Yang, François St-Pierre, Xulu Sun, Xiaozhe Ding, Michael Z Lin & Thomas R Clandinin

*co-first authors

2013 - ACS Synthetic Biology

One-step cloning and chromosomal integration of DNA

François St-Pierre, Lun Cui, David G. Priest, Drew Endy, Ian B. Dodd & Keith E. Shearwin

2008 - PNAS

Determination of cell fate selection during phage lambda infection

François St-Pierre & Drew Endy

2016 - Journal of Neuroscience

Genetically encoded voltage indicators: Opportunities and Challenges

Helen H. Yang & François St-Pierre

2015 - Current Opinion in Chemical Biology

Designs and sensing mechanisms of genetically encoded fluorescent voltage indicators

François St-Pierre, Mariya Chavarha & Michael Z Lin

2013 - Future Microbiology

Repurposing site-specific recombinases for synthetic biology

Lun Cui, François St-Pierre & Keith Shearwin

St-Pierre Lab
@ Baylor College of Medicine